Approaches for plant biosynthetic pathway discovery. Physical co-clustering, co-expression, evolutionary cooccurrence, and epigenetic co-regulation can all be used to identify candidate biosynthetic pathways. Using, for example, network analysis, these approaches can also be
combined, if sufficient data is available. Functionally cohesive modules can then be extracted from such a network and annotated for the presence of genes encoding biosynthesis-related protein families. Finally, modules that have a strong biosynthetic signature can be correlated to metabolite counts or molecular families derived from molecular networking of metabolite data.
Medema and Osbourn (Nat. Prod. Rep., 2016, 33: 951) #bioinformatics #genomics #biochemistry
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