Cachexia is among the most debilitating and life-threatening aspects of cancer. Associated with anorexia, fat and muscle tissue wasting, psychological distress, and a lower quality of life, cachexia can arise from a complex interaction between cancer and the host. This process includes cytokine production, release of lipid-mobilizing and proteolysis-inducing factors, and alterations in intermediary metabolism. Cachexia should be suspected in patients with cancer if an involuntary weight loss of greater than five percent of premorbid weight occurs within a six-month period. Up until recently, the major option for therapy has been pharmacological progestational agents. However, knowledge of the mechanisms of cancer anorexia-cachexia syndrome has led to, and continues to lead to, effective therapeutic interventions for several aspects of the syndrome. As we have known for years, these include cannabinoids, melatonin, and thalidomide--all of which act on the feeding-regulatory circuitry to increase appetite and inhibit tumor-derived catabolic factors to antagonize tissue wasting and/or host cytokine release. Because weight loss shortens the survival time of cancer patients and decreases performance status, effective therapy can extend patient survival and improve quality of life.
We are here to help!
#cancer #cachexia #anorexia #recovery #cbd #cbdoil #hemp #cannabiscommunity #medicalcannabis #medicalmarijuanacard #denvercannabis #boulder #coloradocannabis #coloradocannabiscommunity