Pseudoexfoliation syndrome (PXF or PEX) is an age-related systemic syndrome that targets mainly ocular tissues through the gradual deposition of fibrillary white flaky material from the lens, mainly on the lens capsule, ciliary body, zonules, corneal endothelium, iris and pupillary margin. Higher prevalence of open angle glaucoma in about 50% of these patients.
Exfoliation/Pseudoexfoliation syndrome is a systemic disease. It is most commonly noted in older individuals, typically over 50 years of age.
Exfoliation (pseudoexfoliation) Syndrome is characterized by the fibrillar deposits in the anterior segment of the eye. The deposits have been found on and in the subconjunctival tissue, pupillary margin, ciliary epithelium, lens epithelium, lens capsule, iris pigment epithelium, trabecular meshwork,cornea,zonules, orbital soft tissues, iris stroma and iris blood vessels. These deposits have also been found elsewhere in the body,including in the skin, heart, lungs, liver, kidneys, and elsewhere.
The disease may be bilateral by asymmetric.
It has been associated with myocardial infarction, cerebrovascular events and systemic hypertension.
Etiology is unknown. It may a generalized disorder involving abnormal production or turnover of extracellular matrix in the basement membrane.
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