Pathways affected in single gene, Mendelian hypertension and hypotension syndromes. Some inherited diseases can affect the renal–angiotensin–aldosterone system pathways and, therefore, blood pressure (BP); hypertensive disorders are listed in orange boxes and hypotensive disorders in green boxes.
AME, apparent mineralocorticoid excess;
CLCNKB, chloride channel protein ClC‐Kb; CYP11B1, cytochrome P450 11B1, mitochondrial; CYP17A1,
steroid 17-α‐hydroxylase/17,20 lyase;
CYP21A2, steroid 21‐hydroxylase;
ECaC, epithelial calcium channel;
ENaC; epithelial sodium channel;
GRA, glucocorticoid‐remediable aldosteronism ;
HSD11B2, corticosteroid 11-β‐dehydrogenase isozyme 2;
KCNJ, inward rectifier potassium channel;
MR, mineralocorticoid receptor;
PHA1, pseudohypoaldosteronism, type 1; SLC12A1, solute carrier family 12 member 1; SLC12A3, solute carrier family 12 member 3; TRPM6, transient receptor potential cation channel subfamily M member 6;
WNK1, serine/threonine‐protein kinase WNK1; WNK4, serine/threonine‐protein kinase WNK4.
Oparil S, Acelajado MC, Bakris GL. Hypertension. Nat Rev Dis Primers 2018;4:18014
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